Interstitial pericytes decrease in aged mouse kidneys

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چکیده

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Interstitial pericytes decrease in aged mouse kidneys

With increasing age, the kidney undergoes characteristic changes in the glomerular and tubulo-interstitial compartments, which are ultimately accompanied by reduced kidney function. Studies have shown age-related loss of peritubular vessels. Normal peritubular vessel tone, function and survival depend on neighboring pericytes. Pericyte detachment leads to vascular damage, which can be accompani...

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Pericytes are interstitial mesenchymal cells found in many major organs. In the kidney, microvascular pericytes are defined anatomically as extensively branched, collagen-producing cells in close contact with endothelial cells. Although many molecular markers have been proposed, none of them can identify the pericytes with satisfactory specificity or sensitivity. The roles of microvascular peri...

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ژورنال

عنوان ژورنال: Aging

سال: 2015

ISSN: 1945-4589

DOI: 10.18632/aging.100756